Essays and Musings on Animals and Society

Wednesday, December 17, 2008

Substantial Scientific Flaws of Using Animals in Cancer Research, Part 10 

From a March 2003 editorial in Nature Reviews Drug Discovery (reprinted in What Will We Do If We Don't Experiment On Animals?, by C. Ray Greek, MD and Jean Swingle Greek, DVM):

In Tamoxifen's case, a drug first developed as a potential contraceptive languished for many years before its present application was found. Furthermore, its propensity to cause liver tumours in rats, a toxicity problem that thankfully does not carry over into humans, was not detected until after the drug had been on the market for many years. If it had been found in preclinical testing, the drug would almost certainly have been withdrawn from the pipeline.

Tamoxifen is widely used in the treatment of breast cancer.

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Posted by: Gary / 12:00 PM
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