Essays and Musings on Animals and Society

Wednesday, March 08, 2006

The Futility and Excessive Cruelty of "Modeling" Anorexia Nervosa in Animals 

Humans are the only species to suffer from Anorexia Nervosa (AN). Those afflicted with the disorder have an extreme fear of obesity and an aversion to food. In this article, Jonathan Balcombe, Ph.D., examines the pointless cruelty of studying a contrived, superficially similar version of the condition in rats.

Excerpts:

"[B]ecause rodents don't spontaneously develop eating disorders, experimenters must create 'animal models' of the condition. One such model is the activity-based anorexia (ABA) or semi-starvation-induced hyperactivity (SIH) model, which combines starvation with exercise. Experimenters place rats on a starvation diet and place an activity wheel in their shoebox cage. Perhaps because they are desperate to find food, starved rats show excessive use of the wheel, which accelerates weight loss."

"These studies subject rats to the grinding misery of starvation while frustrating their frenetic efforts to seek and find food. And to what end? Anorexia is a complex syndrome, unique to humans, of primarily psychological origin."

In a follow-up article, Dr.Balcombe shows how human-focused research yields relevant data and theories that could lead to cures and treatments for AN:

"At Israel's Danek Gertner Institute of Human Genetics, a genetic component of AN was studied in 90 family groups with AN tendencies. Two suspect gene polymorphisms were found to be preferentially transmitted to AN offspring, suggesting a genetic predisposition to development of AN."

"At Yale University's Department of Psychiatry, open-ended self-descriptions were obtained from 15 AN patients, 15 control psychiatric patients, and 48 control non-patients between age 14 and 24. AN patients had a significantly heightened and harsh self-reflectivity and they more openly expressed depression and anxiety in their self-descriptions."

Scientists are also conducting epidemiological, brain-scan, and various types of clinical research using human volunteers and actual AN patients.
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